Two‐year prospective study of single infections and co‐infections by respiratory syncytial virus and viruses identified recently in infants with acute respiratory disease
Identifieur interne : 003250 ( Main/Exploration ); précédent : 003249; suivant : 003251Two‐year prospective study of single infections and co‐infections by respiratory syncytial virus and viruses identified recently in infants with acute respiratory disease
Auteurs : Filippo Canducci [Italie] ; Maurizia Debiaggi [Italie] ; Michela Sampaolo [Italie] ; Maria Chiara Marinozzi [Italie] ; Stefano Berrè [Italie] ; Cristina Terulla [Italie] ; Gianluigi Gargantini [Italie] ; Patrizia Cambieri [Italie] ; Egidio Romero [Italie] ; Massimo Clementi [Italie]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 2008-04.
Abstract
A prospective 2‐year analysis including 322 infant patients with acute respiratory disease (ARD) hospitalized in a pediatric department in northern Italy was carried out to evaluate the role as respiratory pathogens or co‐pathogens of recently identified viruses. The presence of respiratory syncitial virus (RSV), human Metapneumoviruses (hMPVs), human Bocaviruses (hBoVs), and human Coronaviruses (hCoVs) was assayed by molecular detection and clinical symptoms evaluated. Nasopharyngeal aspirates from 150 of the 322 infants (46.6%) tested positive for at least one pathogen. Ninety samples (28.0%) tested positive for RSV RNA (61.5% genotype A and 38.5% genotype B), 46 (14.3%) for hMPV RNA (71.7% subtype A and 28.3% subtype B), 28 (8.7%) for hCoV RNA (39.3% hCoV‐OC43, 35.7% hCoV‐NL63, 21.4% hCoV‐HKU1, and 3.6% hCoV‐229E), and 7 (2.2%) for hBoV DNA (of the 6 typed, 50% subtype 1 and 50% subtype 2); 21/150 samples revealed the presence of 2 or more viruses. Co‐infection rates were higher for hMPVs, hCoVs, and hBoV (38.3%, 46.4%, and 57.1%,) and lower for RSV (23.3%). RSV was associated with the presence of complications (P < 0.001) and hypoxia (P < 0.015). When the presence of RSV alone and the RSV‐hMPV co‐infections were considered, RSV mono‐infected patients resulted to have longer hospitalization and higher hypoxia (P < 0.001). The data highlight that (i) RSV has a central role as a respiratory pathogen of infants, (ii) the wide circulation of recently identified viruses does not reduce the clinical and epidemiological importance of RSV, and that (iii) recently identified agents (hMPVs, hBoVs, and hCoVs) act as primary pathogens or co‐pathogens. J. Med. Virol. 80:716–723, 2008. © 2008 Wiley‐Liss, Inc.
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DOI: 10.1002/jmv.21108
Affiliations:
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Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-04">2008-04</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A prospective 2‐year analysis including 322 infant patients with acute respiratory disease (ARD) hospitalized in a pediatric department in northern Italy was carried out to evaluate the role as respiratory pathogens or co‐pathogens of recently identified viruses. The presence of respiratory syncitial virus (RSV), human Metapneumoviruses (hMPVs), human Bocaviruses (hBoVs), and human Coronaviruses (hCoVs) was assayed by molecular detection and clinical symptoms evaluated. Nasopharyngeal aspirates from 150 of the 322 infants (46.6%) tested positive for at least one pathogen. Ninety samples (28.0%) tested positive for RSV RNA (61.5% genotype A and 38.5% genotype B), 46 (14.3%) for hMPV RNA (71.7% subtype A and 28.3% subtype B), 28 (8.7%) for hCoV RNA (39.3% hCoV‐OC43, 35.7% hCoV‐NL63, 21.4% hCoV‐HKU1, and 3.6% hCoV‐229E), and 7 (2.2%) for hBoV DNA (of the 6 typed, 50% subtype 1 and 50% subtype 2); 21/150 samples revealed the presence of 2 or more viruses. Co‐infection rates were higher for hMPVs, hCoVs, and hBoV (38.3%, 46.4%, and 57.1%,) and lower for RSV (23.3%). RSV was associated with the presence of complications (P < 0.001) and hypoxia (P < 0.015). When the presence of RSV alone and the RSV‐hMPV co‐infections were considered, RSV mono‐infected patients resulted to have longer hospitalization and higher hypoxia (P < 0.001). The data highlight that (i) RSV has a central role as a respiratory pathogen of infants, (ii) the wide circulation of recently identified viruses does not reduce the clinical and epidemiological importance of RSV, and that (iii) recently identified agents (hMPVs, hBoVs, and hCoVs) act as primary pathogens or co‐pathogens. J. Med. Virol. 80:716–723, 2008. © 2008 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Lombardie</li></region><settlement><li>Milan</li></settlement></list><tree><country name="Italie"><region name="Lombardie"><name sortKey="Canducci, Filippo" sort="Canducci, Filippo" uniqKey="Canducci F" first="Filippo" last="Canducci">Filippo Canducci</name></region><name sortKey="Berre, Stefano" sort="Berre, Stefano" uniqKey="Berre S" first="Stefano" last="Berrè">Stefano Berrè</name><name sortKey="Cambieri, Patrizia" sort="Cambieri, Patrizia" uniqKey="Cambieri P" first="Patrizia" last="Cambieri">Patrizia Cambieri</name><name sortKey="Canducci, Filippo" sort="Canducci, Filippo" uniqKey="Canducci F" first="Filippo" last="Canducci">Filippo Canducci</name><name sortKey="Canducci, Filippo" sort="Canducci, Filippo" uniqKey="Canducci F" first="Filippo" last="Canducci">Filippo Canducci</name><name sortKey="Clementi, Massimo" sort="Clementi, Massimo" uniqKey="Clementi M" first="Massimo" last="Clementi">Massimo Clementi</name><name sortKey="Debiaggi, Maurizia" sort="Debiaggi, Maurizia" uniqKey="Debiaggi M" first="Maurizia" last="Debiaggi">Maurizia Debiaggi</name><name sortKey="Gargantini, Gianluigi" sort="Gargantini, Gianluigi" uniqKey="Gargantini G" first="Gianluigi" last="Gargantini">Gianluigi Gargantini</name><name sortKey="Marinozzi, Maria Chiara" sort="Marinozzi, Maria Chiara" uniqKey="Marinozzi M" first="Maria Chiara" last="Marinozzi">Maria Chiara Marinozzi</name><name sortKey="Romero, Egidio" sort="Romero, Egidio" uniqKey="Romero E" first="Egidio" last="Romero">Egidio Romero</name><name sortKey="Romero, Egidio" sort="Romero, Egidio" uniqKey="Romero E" first="Egidio" last="Romero">Egidio Romero</name><name sortKey="Sampaolo, Michela" sort="Sampaolo, Michela" uniqKey="Sampaolo M" first="Michela" last="Sampaolo">Michela Sampaolo</name><name sortKey="Terulla, Cristina" sort="Terulla, Cristina" uniqKey="Terulla C" first="Cristina" last="Terulla">Cristina Terulla</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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